RNA Structure Design Improves Activity and Specificity of trans-Splicing-Triggered Cell Death in a Suicide Gene Therapy Approach
نویسندگان
چکیده
Received 28 July 2017; accepted 17 January 2018; https://doi.org/10.1016/j.omtn.2018.01.006. Present address: Institute for Transfusion Medicine and Gene Therapy & Center for Chronic Immunodeficiency at Center for Translational Cell Research (ZTZ), Medical Center University of Freiburg, Freiburg, Baden Württemberg 79106, Germany Present address: EIU Clearstate, Singapore 138567, Singapore Present address: Singapore Science Centre, Singapore 609081, Singapore
منابع مشابه
Spliceosome-mediated RNA trans-splicing facilitates targeted delivery of suicide genes to cancer cells.
Patients suffering from recessive dystrophic epidermolysis bullosa (RDEB), a hereditary blistering disease of epithelia, show susceptibility to develop highly aggressive squamous cell carcinoma (SCC). Tumors metastasize early and are associated with mortality in the 30th-40th years of life in this patient group. So far, no adequate therapy is available for RDEB SCC. An approach is suicide gene ...
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Patients suffering from recessive dystrophic epidermolysis bullosa (RDEB), a hereditary blistering disease of epithelia, show susceptibility to develop highly aggressive squamous cell carcinoma (SCC). Tumors metastasize early and are associated with mortality in the 30th–40th years of life in this patient group. So far, no adequate therapy is available for RDEB SCC. An approach is suicide gene ...
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